Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b
نویسندگان
چکیده
منابع مشابه
Association Between Sunlight Exposure and Vitamin D Intake and Multiple Sclerosis Disability and Progression
Background: Some studies on Multiple Sclerosis (MS) have suggested that adequate vitamin D intake can modulate the course of MS and decreases its incidence. However, there are limited studies with conflicting findings on the relation between MS severity, its course, and vitamin D intake. Objectives: The current study aimed to compare vitamin D intake and sunlight exposure between MS phenotype...
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Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients w...
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Recombinant interferon beta-1b (IFNβ-1b) was the first approved disease-modifying therapy for patients with multiple sclerosis (MS) by the world regulatory agencies for medical drugs and devices. IFNβ-1b significantly decreases the inflammatory component of MS but still has doubtable effect on the neurodegenerative component. This article appraises the beneficial effects of IFNβ-1b on clinical ...
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A single nucleotide polymorphism (SNP) in CD24 has been associated with multiple sclerosis (MS) in a population based study. This SNP results in the replacement of alanine (CD24A) by valine (CD24V) at amino acid 57 in the resulting polypeptide chain. In the current study, the genotyping of this SNP and its contribution to MS in 217 patients and 200 healthy individuals of an Iranian population w...
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ژورنال
عنوان ژورنال: JAMA Neurology
سال: 2015
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2015.2742